Cognitive impairment and psychiatric manifestations in HIV and HCV
Research type
Research Study
Full title
Cognitive and Psychiatric manifestations in Human Immunodeficiency Virus [HIV] and Hepatitis C Virus [HCH] co infection population undergoing HCV treatment.
IRAS ID
143289
Contact name
Renata Fialho
Contact email
Sponsor organisation
University of Sussex
Research summary
An alarming incidence of new cases and reinfection of co infection with HIV and HCV has been reported (Lambers et al, 2011). Reinfection was defined as having HCV infection following a positive treatment outcome (Lambers et al, 2011). This reinfection behaviour needs to be understood to prevent relapses and decreased incidence of HCV infections. The neuropsychiatric side effects related with HCV therapy in co infected HIV HCV patients include depressive symptoms, anxious symptoms and cognitive symptoms(Fried, 2002; McHutchinson et al, 1998; Okanoue et al, 1996; Trask et al, 2000; Valentine et al, 1998, Capuron and Miller, 2004, Capuron et al, 2000). Few studies have been carried out regarding the specific cognitive changes and psychiatric manifestations in the co infected HIV HCV patients undergoing HCV treatment. \n\nThe present study aims to assess the prevalence and implications of cognitive impairment and psychiatric manifestations in patients infected with both HIV and HCV virus undergoing hepatitis C treatment. The HCV treatment duration is 72 weeks. Is a cross sectional study design that will be performed in the Digestive Unit Clinic at the Brighton Sussex University Hospital (BSUH). We will use semi-structured clinical interviews including socio-demographic information, clinical data, behavioural and cognitive instruments. This research will result in a real description of the cognitive and neuropsychiatric side effects among this clinical population. This is an important study as it may not only help identify patients who are cognitively impaired but also may provide important insight regarding reinfection behaviour. \n
REC name
East of England - Cambridgeshire and Hertfordshire Research Ethics Committee
REC reference
14/EE/0094
Date of REC Opinion
10 Apr 2014
REC opinion
Further Information Favourable Opinion