COGNITION study
Research type
Research Study
Full title
Assessing the efficacy of CardiOGoniometry (CGM) to localise the culprit vessel in mixed vessel disease Non-ST elevatIon myocardial infarcTION (NSTEMI) - COGNITION
IRAS ID
174325
Contact name
Oliver Brown
Contact email
Sponsor organisation
Hull and East Yorkshire Hospitals NHS Trust
Duration of Study in the UK
0 years, 11 months, 31 days
Research summary
We aims to investigate whether Cardiogoniometry (CGM) is helpful at identifying which blood vessel is blocked in patients who have had a heart attack when it is not clear which vessel has been affected called non-ST elevation myocardial infarction (NSTEMI). We will be comparing CGM to 12-lead electrocardiogram (ECG) which is a 2-dimensional tracing of the heart’s electrical activity and using a special test called optical coherence tomography (OCT) as the “gold standard”.
The ECG is a test commonly used to help diagnosis a heart attack, but in patients with NSTEMI it is not clear which blood vessel the blockage has occurred in. Furthermore when you introduce dye into the heart’s blood vessel to try find the blockage it is not always possible to identify the culprit blood vessel as many patients have more than one diseased blood vessel. A special test called OCT can be used to help identify the vessel which is blocked by using special light waves to make detailed images of the heart’s blood vessels. However OCT is expensive and means that it cannot be used in all patients.
CGM is a special form of 3-dimensional ECG which has been shown to be better than normal ECG at diagnosing angina and heart attacks. In addition to this, it is cheap and non-invasive and we hope can identify the vessel which is blocked without the use of OCT.
This question has not been answered before and it is important to know if this test could be useful in investigating patients with NSTEMI. We aim to have 30 patients in this study. The cardiology department at Castle Hill Hospital currently undertakes approximately 36 procedures per month for this indication of which 56% have multivessel disease; therefore we aim to realistically recruit 2-3 patients a month.
REC name
Yorkshire & The Humber - Bradford Leeds Research Ethics Committee
REC reference
15/YH/0270
Date of REC Opinion
18 Aug 2015
REC opinion
Further Information Favourable Opinion