COG-PBC
Research type
Research Study
Full title
Assessing cognitive impairment in primary biliary cirrhosis (COG-PBC)
IRAS ID
237954
Contact name
Amardeep Khanna
Contact email
Sponsor organisation
Newcastle upon Type Hospitals NHS Foundation Trust
Clinicaltrials.gov Identifier
8695, R&D ref number
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
The purpose of the research is to find out more about the symptoms that some PBC patients get called cognitive symptoms. These are things like memory problems, recalling words and following a list of instructions. We also want to work out whether having these symptoms means that changes have happened to the brain. If the brain does change we want to see if it happens before or after the cognitive symptoms start. At the moment there are no treatments specifically for the prevention or treatment of cognitive symptoms in PBC and there are no trials going on. Before this kind of drugs trial can be done we need to find out more detail about cognitive symptoms by using questionnaires, computerised tests and puzzles. We need to find out whether these questionnaires, computerised tests and puzzles are good enough to pick up very small differences in patients and whether patients find them okay to do. We also want to work out whether having these symptoms means that changes have happened to the brain so we need to do a brain scan. If the brain does change we want to see if it happens before or after the cognitive symptoms start so we will compare PBC and other patients with and without symptoms. Doing this study will help plan for a future drugs trial with more patients. Being involved in the study would involve 1 extra visit to hospital which will take 3-4 hours where participants will undergo various questionnaires for cognitive testing and a MRI scan of the brain.
REC name
North West - Greater Manchester Central Research Ethics Committee
REC reference
18/NW/0119
Date of REC Opinion
22 Mar 2018
REC opinion
Further Information Favourable Opinion