CoDuBu project (Cote d'Ivoire Dual Burden of Disease Project)
Research type
Research Study
Full title
CoDuBu project: Côte d’Ivoire Dual Burden of Disease
IRAS ID
246101
Contact name
John W.
Contact email
Sponsor organisation
University of Southampton
Clinicaltrials.gov Identifier
032/IMSHP/CNER-kp, Ethics approval Cote d'Ivoire; 2016-00143, Ethics approval Switzerland; ISRCTN87099939, International Standard Randomized Controlled Trials Number; http://www.researchprotocols.org/2017/10/e210/, Study protocol open access publication link; 129-18/MSHP/CNESVS-km, Ethics approval Cote d'Ivoire (2018)
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
The co-occurrence of infectious diseases and non-communicable diseases is poorly studied, despite the fact that this dual burden has become a reality for many low- and middle-income countries (LMICs). Even very little is known about how common infectious diseases (e.g. worms and malaria) and non-communicable diseases (e.g. high blood pressure and diabetes) influence each other. Repeated and chronic infections that are common in LMICs may alter people’s susceptibility to diabetes and heart disease. Worm infections may shift the immune system into a direction protecting against inflammatory diseases, whereas repeated infections such as malaria may increase the risk of inflammatory diseases. If confirmed, there is a need for changes in the provision of health services towards effective combined managament. The aim of this study was therefore to carry out a survey of adults (and set up a biobank consisting of blood, urine and stool samples stored at -80°C for future research into disease mechanisms) from rural and urban parts of the Taabo district in south-central Côte d’Ivoire, to study the co-occurrence of worm infections and malaria with metabolic syndrome, high blood pressure and diabetes.
Specifically, blood samples collected on filter papers as part of this project will be imported into UK for DNA extraction as well as measuring the level of DNA methylation ( a chemical modification to DNA that can occur in response to exposures). We will assess the effect of malaria parasitemia and glycaemia (or diabetes) on DNA methylation profiles of the participants, to identify any shared molecular pathways by both pathologies. Evidence gained in this regard will go towards improving our understanding of causal mechanisms as well as potential identification of new diagnostic and treatment targets, and better integrated disease management.REC name
North West - Greater Manchester East Research Ethics Committee
REC reference
19/NW/0134
Date of REC Opinion
11 Mar 2019
REC opinion
Favourable Opinion