CODEC Study
Research type
Research Study
Full title
Chronotype of Patients with Diabetes and Effect on Glycaemic Control: The CODEC Study
IRAS ID
202758
Contact name
Melanie Davies
Contact email
Sponsor organisation
Univeristy of Leicester
Duration of Study in the UK
4 years, 6 months, 1 days
Research summary
There has been considerable interest in the association between quantity and quality of sleep and circadian rhythms and the development of cardio-metabolic disease especially metabolic syndrome, type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). The identification of these different chronotypes which describes preferred circadian phases, into, at the two extremes, 'morning type' and 'evening type' has led to further research confirming that 'evening types' are at greater risk of cardio- metabolic disease. The underlying causes have not been clearly defined but appear to be related to circadian misalignment causing chronic sleep deprivation and leading to dysregulation of metabolic, immune and hormonal processes that govern energy regulation and glycaemic control.
In this cross-sectional observational study, we therefore propose to extensively chronotype a sample of patients with T2DM, and to determine the impact of chronotype on glycaemic control, insulin resistance, biochemical profile, inflammatory, adipocytokine and genetic markers using a validated questionnaire and blood tests. The aim of the study is to explore the associations between chronotype and glycaemic control, cardiometabolic health and other lifestyle factors.REC name
West Midlands - Black Country Research Ethics Committee
REC reference
16/WM/0457
Date of REC Opinion
16 Nov 2016
REC opinion
Further Information Favourable Opinion