COAST study
Research type
Research Study
Full title
Evaluation of COronary blood flow in patients with severe Aortic Stenosis treated with Transcatheter aortic valve replacement (COAST study)
IRAS ID
255057
Contact name
Rajesh Aggarwal
Contact email
Sponsor organisation
Basildon and Thurrock University Hospitals NHS Foundation Trust
Clinicaltrials.gov Identifier
ANZCTR Trial ID, ACTRN12618000403235
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Aortic stenosis is the commonest valve pathology requiring medical intervention. Aortic stenosis causes restriction and alterations in blood flow to the rest of the body including the coronary arteries which can cause symptoms of fatigue, breathlessness, chest pain and dizziness. Transcatheter aortic valve implantation (TAVI) is a minimally invasive procedure where a new valve is inserted inside the old narrowed valve using a balloon catheter. This can relieve the symptoms as blood can once again be pumped freely to the rest of the body without the additional effort.
Existing data suggests that this procedure allows partial restoration of normal blood flow to the coronary arteries. However, it remains unclear what the longer term effects of this procedure are. This an important consideration as it will enable us to have a better understanding of this treatment. We aim to conduct assessment in 30 patients undergoing TAVI using cardiac CT, echocardiography and coronary flow measurements around the index procedure and at 6-9 months follow up. We expect to see that there is further restoration of normal coronary physiology at follow up after TAVI.
REC name
East of England - Cambridge East Research Ethics Committee
REC reference
19/EE/0197
Date of REC Opinion
26 Jul 2019
REC opinion
Further Information Favourable Opinion