Coagulopathy Biomarkers in Cardiac Surgery
Research type
Research Study
Full title
Evaluation of Coagulopathy Biomarkers in Adult Cardiac Surgery
IRAS ID
243684
Contact name
Andrew Mumford
Contact email
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
The overarching objective of this study is to improve the way abnormalities in the blood clotting system are detected and treated in patients having open heart surgery. This is important because blood clotting abnormalities are common during heart surgery and can lead to harmful bleeding. However, previous research from our team and others has shown that currently available NHS blood tests performed during heart surgery does not allow accurate identification of which patients will go on to develop severe bleeding.
The aim of our new research study is to explore whether performing different laboratory tests of the blood clotting system are feasible and demonstrate abnormal results. This will be achieved using small volumes of spare blood taken from the heart bypass machine used during open heart surgery. The particular focus will be measuring levels of components of the blood coagulation system that we believe are abnormal during heart surgery, but which are not detected using currently available NHS tests. We will also explore whether these blood clotting abnormalities are more easily detected using blood samples taken from different parts of the heart bypass machine than is used currently to monitor patients. If we detect major abnormalities using new kinds of test, then we will also examine the effect of potential treatments to reverse blood clotting abnormalities added to the blood samples in the laboratory.
The results of our exploratory study will give more mechanistic information about how blood clotting abnormalities develop during heart surgery and will be used to refine laboratory testing procedures for new tests. This information will be used to assist design of future larger scale clinical studies to study the clinical utility of new laboratory tests.
REC name
London - City & East Research Ethics Committee
REC reference
19/LO/0336
Date of REC Opinion
18 Feb 2019
REC opinion
Favourable Opinion