Co-morbidity and Refractory Asthma - UK Severe Asthma Registry
Research type
Research Database
IRAS ID
359181
Contact name
Liam Heaney
Contact email
Research summary
UK Severe Asthma Registry
REC name
HSC REC B
REC reference
25/NI/0084
Date of REC Opinion
22 Jul 2025
REC opinion
Further Information Favourable Opinion
Data collection arrangements
The Registry records patient demographics including gender, age at diagnosis, race, occupation, smoking status,BMI, and disease characteristics such as asthma medication, unscheduled healthcare visits, exacerbations, hospital and
ICU admissions, blood and sputum investigations, allergen testing, and pulmonary function.
The aims of the Registry are to facilitate research into the assessment and clinical management of difficult asthma.
Individual Centre data is available for local audit and service review in the various centres submitting data to the registry. Data will only be released for use in research on application to the steering committee of the UK difficult
asthma registry co-ordinated by Professor Heaney and following appropriate ethical approval.Research programme
The Registry has the potential to provide and has already provided substantial information on Difficult and Refractory Asthma in the UK. The Registry is designed to provide longitudinal follow-up data, and has large numbers which allow sub-group analysis within the population of refractory asthma, which is lacking in this area. The Registry will be used to inform on issues such as clinical outcomes, prevalence and role of co-morbidity, evaluation of specific interventions in severe asthma and health economics of severe asthma in the UK. Data from the Registry has been used to investigate clinical outcomes and phenotypes of severe asthma, smoking status in severe asthma, effects of age on clinical outcomes in severe asthma, the cost of severe asthma in the UK, prevalence of steroid induced morbidity in severe asthma and the data is being used for an audit of the safety of bronchial thermoplasty in severe asthma. (see UK SAR Publications July 2024)
Research database title
UK Severe Asthma Registry