CMR Perfusion and Viability
Research type
Research Study
Full title
Improved prediction of functional recovery after revascularisation using combined assessment of myocardial ischaemia and viability by Cardiovascular Magnetic Resonance – pilot study
IRAS ID
247309
Contact name
Amedeo Chiribiri
Contact email
Sponsor organisation
King's College London
Duration of Study in the UK
3 years, 2 months, 31 days
Research summary
Heart failure is a common condition that adversely affects the quality of life and longevity of sufferers. The most common cause is narrowing of the heart arteries, which leads to irreversible scarring of the heart muscle or causes the heart muscle to enter a state called hibernation, where it remains alive but inactive. Invasive treatment of heart arteries can restore function if the muscle is hibernating but not if it is scarred and so, distinguishing these states is the key to selecting patients who will benefit. Currently available tests, including nuclear and MRI scans, have only limited accuracy at predicting whether the heart muscle will recover if the blockages are treated.
We aim to evaluate a new test called “high resolution perfusion combined with scar imaging”, where we assess the heart's blood flow and scar levels during a cardiac MRI scan. We will see if this test is more accurate than those currently available at predicting which patients will benefit from receiving invasive treatment to increase the blood supply to the heart.
We will ask people with heart failure who are due to have a by-pass operation if they want to take part in the study. The only difference to standard clinical care will be each participant will have a cardiac MRI scan (including our new high resolution test), an echocardiogram and a 6 minute walk test performed at the start of the study and again 12 months after the bypass operation to see how well the heart recovered, and how well our test predicted this. This study will not change how the surgery is performed. This study will be conducted in a hospital that is a centre of excellence in this type of cardiac research.
REC name
East of Scotland Research Ethics Service REC 1
REC reference
18/ES/0115
Date of REC Opinion
24 Oct 2018
REC opinion
Further Information Favourable Opinion