CMR CHD
Research type
Research Study
Full title
ADVANCED CARDIOVASCULAR MAGNETIC RESONANCE TECHNIQUES TO IDENTIFY NOVEL IMAGING BIOMARKERS OF DISEASE PROGRESSION AND THERAPEUTIC RESPONSE IN CONGENITAL HEART DISEASE.
IRAS ID
226433
Contact name
Victoria/ VM Stoll
Contact email
Sponsor organisation
University of Birmingham
Duration of Study in the UK
12 years, 0 months, 1 days
Research summary
The function of the heart is to act as a pump for the blood. The heart has two pumping chambers; in most people the pumping chamber on the right pumps blood to the lungs, whilst the pumping chamber on the left pumps blood around the body. Some people have a heart condition where the pump that is usually the right sided pump ends up in a position where it pumps the blood around the body instead. Over time this pump in an abnormal position will start to deteriorate and eventually fail and cause problems such as breathlessness.
New cardiovascular magnetic resonance techniques allow the study of blood flow within the heart in all directions over time. Using this technique this study will assess the flow patterns in patients with their right sided heart pump supplying their body and compare them to healthy people where their right sided pump supplies their lungs. This will allow assessment of what changes have occurred to blood flow patterns within the pumping chamber in the abnormal position compared to healthy people with normal pump positions. How efficiently the heart pumps blood affects how much exercise people can undertake. Our study participants will undertake controlled exercise to see how long and hard they can exercise for. We shall then use the information from the changes seen in the blood flow patterns to see if they appear to be related to how well these patients can exercise. We will also observe whether any changes found in the flow patterns relate to how patients progress over time.
45 participants will be recruited. We will study matched healthy participants, patients born with their right ventricle in the abnormal position who did not need surgery and patients with a right sided pump connected to the body following surgery.
REC name
East Midlands - Leicester Central Research Ethics Committee
REC reference
17/EM/0319
Date of REC Opinion
26 Sep 2017
REC opinion
Further Information Favourable Opinion