CMR Airway Disease
Research type
Research Study
Full title
Right Heart Dysfunction and Pulmonary Hypertension Evaluation in Airway Disease Using Cardiac Magnetic Resonance
IRAS ID
171377
Contact name
Sumit Gupta
Contact email
Sponsor organisation
University of Leicester
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
Assessment of Heart in Airway Disease Using Cardiac Magnetic Resonance Imaging
Poor function of the right side of the heart and rise in pressure of the blood vessels leading to the lungs are two main heart-related factors that are associated with worsening of airway disease A relatively new method which uses magnetic field to create images of the heart called cardiac magnetic resonance (CMR) imaging shows immence promise in detailed and accurate assessment of the heart in patients with airway diseases. This project aims to assess the heart in patients with asthma and chronic obstructive pulmoanry disease (COPD) as well as healthy participants using CMR to help us determine features on CMR that are different is patients with asthma and COPD compared to healthy particpants. This may help with early identification of patients who are at risk of episodes of acute worsening of airway disease, called exacerbation, and potentially halt the progression of the heart dysfunction with currently available or new treatments.
Study involves one visit at Glenfiled Hospital, Leicester, lasting approximately 4 hours. The visit will include following assessments: clinical history, health status, physical examination, electrocardiogram (ECG), blood tests, lung function testing, echocardiogram and CMR. Part of the study will involve a participant questionnaire in which the participants will rate their CMR experience. The results will potentially change the way CMR is undertaken. A sub-set of the participants will also be invited back to do a one off focus group discussing the CMR experience further.
The study is funded by The Royal College of Radiologists Pump Priming Grant and The Academy of Medical Science Starter Grant for Clinical Lecturers with additional support from National Institute of Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, NIHR Leicester Cardiovascular Biomedical Research Unit and Radiology Department University Hospitals of Leicester NHS Trust.REC name
East Midlands - Leicester South Research Ethics Committee
REC reference
16/EM/0163
Date of REC Opinion
23 Jun 2016
REC opinion
Further Information Favourable Opinion