CLS Cohorts Human Tissue Bank

• Research type

  Research Tissue Bank

• IRAS ID

  263102

• Research summary

  CLS Cohorts Human Tissue Bank

• REC name

  North West - Haydock Research Ethics Committee

• REC reference

  19/NW/0710

• Date of REC Opinion

  23 Dec 2019

• REC opinion

  Favourable Opinion

• Data collection arrangements

  All samples currently in the tissue bank were collected from three unique and powerful longitudinal cohort studies run by the Centre for Longitudinal Studies at the UCL Institute of Education: the 1958 birth cohort (also know as the National Child Development Study), the 1970 British Cohort Study and the Millenium Cohort Study. The 1958 birth cohort study (NCDS) recruited over 17,000 individuals who were born in one week in 1958. The 1970 British Cohort Study (BCS) follows the lives of those born in one week in 1970. And the most recent of Britain’s renowned national longitudinal cohort studies, the Millenium Cohort Study (MCS), follows the lives of over 19,000 children in the UK born in 2000/1. The subjects in these studies have been well characterised (phenotyped) for a variety of quantitative complex traits and been assessed for a variety of sociodemographic, socioeconomic and lifestyle variables.

  The samples include blood samples, DNA, cell lines and saliva. 

  The resource is widely used for research in genetic and genomic epidemiology, in particular as a platform for genetic association studies.

  All samples from these cohort studies were (and will be) collected with generic consent for future research.

  Samples are stored at the Bristol Bioresource Laboratories at the University of Bristol.

• Research programme

  Research will be undertaken across a wide range of phenotype−genotype associations. For example asthma, diabetes, growth and metabolism but will not restricted to these conditions. In addition the tissue bank may use samples or data derived from the samples to undertake research related to the development of biobank methodology. For example research into the characteristics of cell line growth related to DNA yield, suitability of different sample types for analytical methodology, or research into standardisation of DNA quantification methodology may be undertaken.

• Storage license

  12512

• RTBTitle

  CLS Cohorts Human Tissue Bank

• Establishment organisation

  Centre for Longitudinal Studies

• Establishment organisation address

  UCL Institute of Education

  20 Bedford Way

  WC1H 0AL