Clot structure in anaemia
Research type
Research Study
Full title
Influence of Anaemia on Clot Structure
IRAS ID
159067
Contact name
Paraskevi Untiveros
Contact email
Sponsor organisation
University of Aberdeen/NHS Grampian
Duration of Study in the UK
2 years, 11 months, 30 days
Research summary
Anaemia is an important risk factor for the development of blood clots. Clot structure in anaemic patients has not been investigated.
In order to study this blood will be sampled from several groups of anaemic patients: myeloproliferative disease, sickle cell anaemia and autoimmune haemolysis. Non-anaemic volunteers with myeloproliferative disease, sickle cell trait and healthy volunteers will also be recruited for comparison. Blood samples taken from volunteers will be used to form clots in a laboratory. Different aspects of the blood clots will be examined for example speed of clot formation, firmness, pore size and speed of clot break down. The effects of aspirin, hydroxycarbamide therapy and blood transfusion on clot structure in these group of patients will also be investigated.
The results will give us a better understanding on the role anaemia plays in the development of blood clots. This work could provide a laboratory model to test new drugs for the treatment or prevention of blood clots. Our results may lead to the use of a new tool to distinguish anaemic patients at higher risk of developing clots.
REC name
Yorkshire & The Humber - Leeds East Research Ethics Committee
REC reference
14/YH/1230
Date of REC Opinion
23 Oct 2014
REC opinion
Favourable Opinion