Clinical significance of IGC and IPF in diagnosing neonatal sepsis
Research type
Research Study
Full title
The clinical significance and use of immature granulocytes count and immature platelet fractions in diagnosis of neonatal sepsis.
IRAS ID
202873
Contact name
Carlos Fenoo
Contact email
Sponsor organisation
Barking,Havering and redbridge NHS Trust
Duration of Study in the UK
0 years, 1 months, 13 days
Research summary
The study is an academic research for an MSc award. It involves mainly data analysis of Immature granulocytes, also called white blood cells, count(IGC) and immature platelet fractions(IPF) following routine full blood count of neonatal samples. IGC and IPF are generated as part of parameters during full blood count.
Physiological immature state of the neonatal immune system and reduced levels of preformed maternal(mother) antibodies in preterm infants alongside organ immaturity contribute to a disturbed equilibrium of pro-and anti-inflammatory factors resulting in a reduced immune defence making the neonates more susceptible for sepsis and its complications.
Results generated by full blood count(FBC) analyser will be accessed daily to check for neonatal results, and from here IGC and IPF will be recorded manually onto a spread sheet. From this information, the data will be analysed and compared to normal ranges for neonates with and without sepsis to predict the pattern of IGC and IPF in diagnosing neonatal sepsis.
Since FBC is the most frequent test done, and it is cheap and one sample gives multiple parameters, if IGC and IPF proof to be useful in early detection and monitoring of neonatal sepsis, it will save newborn babies lives and money for the health service.REC name
East of Scotland Research Ethics Service REC 2
REC reference
16/ES/0043
Date of REC Opinion
18 Mar 2016
REC opinion
Further Information Favourable Opinion