Clinical Significance of Circulating Biomarkers in the Critically Ill
Research type
Research Study
Full title
Investigation of the Clinical Significance of Circulating Biomarkers in the Critically Ill
IRAS ID
238659
Contact name
John Geen
Contact email
Sponsor organisation
Cwm Taf University Health Board
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Sepsis is a serious illness in which an infection can result in multiple organ failure and death. Rapid diagnosis of sepsis is important as early treatment is associated with improved outcomes for the patient. Currently, the diagnosis of sepsis relies on time-consuming microbial culture and assessment of blood proteins. The aim of this project is to determine the clinical significance of a range of biomarkers in the blood associated with immunological function, inflammation, infection and repair mechanisms in critically ill patients. The biomarkers under investigation will include actin, gelsolin, chondroitin sulphate, alpha-1 antitrypsin, Gc-globulin (also known as vitamin-D binding protein) which will be used with total vitamin-D to calculate the biologically active and free vitamin-D concentrations. These biomarkers will be measured in stored blood samples that have previously been collected from critically ill patients staying in Intensive Care. All samples and clinical information have been collected for previous research therefore further participant involvement is not required for this study. The project will aim to identify further biomarkers that may contribute to susceptibility, causation or identification of sepsis in patients, and differentiation from severe inflammation.
REC name
London - Camden & Kings Cross Research Ethics Committee
REC reference
18/LO/1891
Date of REC Opinion
26 Oct 2018
REC opinion
Favourable Opinion