Clinical Records Management System for inflammatory arthritis
Research type
Research Database
IRAS ID
207472
Contact name
Costantino Pitzalis
Contact email
Research summary
Clinical Records Management System for inflammatory arthritis
REC name
East of England - Cambridge East Research Ethics Committee
REC reference
17/EE/0119
Date of REC Opinion
5 May 2017
REC opinion
Further Information Favourable Opinion
Data collection arrangements
Currently upwards of 400 patients suffering from inflammatory arthritis (predominantly Rheumatoid and psoriatic arthritis) have been recruited to primarily to synovial biopsy based studies led by the centre for Experimental Medicine and Rheumatology at Barts Health NHS Trust. Patients within the cohort have been recruited at varying disease stages including at disease onset (PEAC, Pathobiology of Early Arthritis cohort), following failure to respond to traditional disease modifying anti-rheumatic drugs (DMARDs) (THERAPIST, STRAP) and following the failure on first line biologic therapy (R4RA study).
The CRMSIA database proposed intends to act as a central repository for all clinical data collected within clinical trials within the department of Rheumatology, Barts Health NHS Trust led by Experimental Medicine and Rheumatology for which QMUL is the study sponsor. The intention would be to continue to follow these patients on their return to routine NHS rheumatology clinic, collecting data recorded within routine follow up visits.
Research programme
CRMSIA offers a unique opportunity to collect an integrated pathophysiological/clinical longitudinal dataset of a unique cohort of patients offering the opportunity to evaluate the progression, modulation and development of synovial pathobiology in line with disease progression and response/non response to treatment.
Research database title
Clinical Records Management System for inflammatory arthritis
Establishment organisation
Centre for Experimental Medicine & Rheumatology, Queen Mary University London
Establishment organisation address
2nd Floor John Vane Science Centre, William Harvey Research Institute
Barts and the London School of Medicine
Queen Mary University London
EC1M 6BQ