Clinical picture of the patterns of chronic cough version 1.0
Research type
Research Study
Full title
An Observational Study using novel questionnaire to characterize Cough phenotypes in Patients with Chronic Cough
IRAS ID
314503
Contact name
Caroline Wright
Contact email
Sponsor organisation
Hull University Teaching Hospitals NHS Trust
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Studying Chronic cough (CC) for 25 years I have noticed patients have different patterns of cough during the day. Some patients have a persistent cough, whereas others suffer from severe bursts with little cough in-between. Never has the difference in pattern of cough been studied between CC patients. Objective measuring of cough is via recording the total number of coughs over 24hrs, this is a simple figure and gives no indication of the rise and fall of the cough through out the day. In many studies changes in objective cough doesn’t match changes in subjective measures. It is possible those patients who have significant intense bursts of cough do not notice a change in the number of coughs during the burst and therefore record no subjective changes. I believe the pattern of cough could prove important in understanding why some patients in clinical studies of cough treatments are found to be responders and others non responders. It may also be possible to charactize patients likely to have a placebo response which is a common phenomenon in studies of chronic cough therapies.\nPart 1 of the Study would involve recruiting 30 patients with a chronic cough from cough clinic and they will be asked to complete my simple ’Pattern of cough characterisation questionnaire, this will allow me to establish what patterns of cough this cohort of patients have. Based on the data collated from part 1 the questionnaire will be updated if necessary and the 2nd part of study will look at reproducibilityand validity of updated questionnaire. In the second part, 30 patients will be presented with the questionnaire on three separate occasions, and the data from the three questionnaires will be compared to determine its reproducibility. A subset of these patients will perform 24hr cough monitoring to help validate the questionnaire.\n\n
REC name
South West - Central Bristol Research Ethics Committee
REC reference
22/SW/0090
Date of REC Opinion
22 Jul 2022
REC opinion
Further Information Favourable Opinion