Clinical impact of MI on inhaled antibiotic adherence in CF
Research type
Research Study
Full title
Assessing the clinical impact of motivational interviewing on inhaled antibiotic adherence in cystic fibrosis
IRAS ID
158685
Contact name
Damian Downey
Contact email
Sponsor organisation
Belfast Health and Social Care Trust
Clinicaltrials.gov Identifier
QUB Co-sponsor reference number, B14/40
Research summary
The treatment of cystic fibrosis (CF) involves numerous different components, including enzyme supplementation, nutritional therapy, physiotherapy and exercise, thus, adherence is a challenge. Adults commonly experience chronic Pseudomonas aeruginosa (Pa) lung infections, with periodic acute flare-ups characterised by worsened respiratory symptoms. This accelerates the deterioration of the lungs and increases mortality. Management with long-term inhaled antibiotics is therefore crucial to maintain lung function and reduce acute flare-ups; however, adherence to inhaled therapy is known to be particularly poor.
Strategies for changing behaviour to increase adherence should result in improved patient outcomes. Motivational interviewing (MI) is a special type of conversation style that has been used to help people make changes that are difficult yet beneficial, such as making changes to ensure that prescribed therapies are taken as directed. This study will investigate the use of MI to improve adherence to inhaled antibiotics in adult CF patients with chronic Pa infection, and, the impact of such changing adherence on the patient. Patients taking inhaled antibiotics for =3 months before enrolment will be recruited from CF clinics at Belfast Health and Social Care Trust. Participation will include five clinic visits (at the beginning then 1, 2, 4 and 6 months) and one follow up phone call (3 months). Visits will be arranged to coincide with the normal clinic. Three questionnaires will be completed by patients at each of the 5 visits and MI will be part of the first three visits (at the beginning, 1 month, 2 months). Sputum samples will also be collected from patients at the visits.
It is hoped that MI will increase adherence and that such improved adherence will result in direct patient benefits including improved lung function, the reduced need for additional antibiotics and an increased quality of life.REC name
HSC REC A
REC reference
14/NI/1096
Date of REC Opinion
16 Oct 2014
REC opinion
Further Information Favourable Opinion