Clinical Evaluation of Novel Coronary MRI Techniques
Research type
Research Study
Full title
Clinical Evaluation of Novel 3-Dimensional Magnetic Resonance Angiography Sequences for the Identification and Characterisation of Coronary Disease
IRAS ID
230350
Contact name
Rene Botnar
Contact email
Sponsor organisation
King's College London
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
2 years, 7 months, 0 days
Research summary
Coronary artery disease (CAD) is the single leading cause of morbidity and mortality in the Western World. CAD reduces the blood supply to the cardiac muscle and can lead to chest pain or heart attack. CAD is detected by a range of invasive and non-invasive tests. However, in current practice a non-negligible number of patients are referred for invasive cardiac cathetiseration or non-invasive computed tomography (CT) procedures that require exposure to ionising radiation and administration of iodinated contrast, both of which are potentially harmful. Cardiovascular magnetic resonance angiography (CMRA) is a promising modality for identification of CAD without exposure to ionising radiation or administration of intravenous contrast. Furthermore, as cardiovascular magnetic resonance imaging is now an established technique for the assessment of cardiac function and tissue characterisation (including viability and perfusion), the development of CMRA could allow for comprehensive cardiac assessment using a single imaging modality. To date, a number of technical challenges have limited the use of CMRA in the clinical assessment of CAD, however, recent advances in motion-correction and accelerated imaging techniques have made CMRA a potentially useful tool for the clinical assessment of CAD. In this research study we aim to assess the diagnostic accuracy of novel CMRA sequences against the clinically established investigation of CT coronary angiography (CTCA), which is the non-invasive reference standard for assessment of CAD. Where a clinically indicated invasive coronary angiogram or functional test is performed following CTCA/CMRA, we will compare the diagnostic accuracy of CMRA to CTCA, provided patients provide written consent allowing them to be contacted 6-months following CMRA. The study will be an important step towards widespread clinical adoption of CMRA and the efficient and accurate non-invasive assessment of CAD.
REC name
South Central - Hampshire B Research Ethics Committee
REC reference
18/SC/0441
Date of REC Opinion
8 Aug 2018
REC opinion
Favourable Opinion