Clinical effectiveness of CPET in predicting outcomes of Whipple
Research type
Research Study
Full title
CLINICAL EFFECTIVENESS OF PRE-OPERATIVE CARDIOPULMONARY EXERCISE TESTING (CPET) IN PREDICTING POST-OPERATIVE MORBIDITY AND MORTALITY AFTER PANCREATODUODENECTOMY – A RETROSPECTIVE COHORT STUDY
IRAS ID
284588
Contact name
ASMA SULTANA
Contact email
Sponsor organisation
Royal Blackburn Hospital, East Lancashire Hospitals NHS Trust
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Pancreatic resections, particularly Pancreatoduodenectomy, is considered the standard modality of management for pancreatic head and periampullary tumours. The morbidity and mortality associated with the procedure, has improved in the recent times, but it still remains high. Post-operative pancreatic fistula (most serious complication),in particular, has an incidence ranging from 20-25%. The operability of the tumour not only depends on the initial staging of the tumour, but also on physiological status of the patient, fitness, pre-existing comorbidities and age. The use of cardiopulmonary Exercise Testing (CPET), in assessing physiological status of the patient has been in discussion, in the past two decades. The clinical effectiveness and use of CPET as a guide for pre-operative optimisation of the patient undergoing major abdominal surgeries, has been proven. The latest NICE guidelines for Pancreatic cancer and management updated in 2018, does not include guidelines on including CPET as a part of pre-operative assessment.
With the above mentioned background, we aim to do a retrospective analysis of patients who have undergone pancreatic resections, at our centre. The aim is to assess the ability of physiological parameters assessed by CPET, in predicting post-operative morbidity and mortality. This study also aims at evaluating and analysing a group of patients who did not have CPET and assess their perioperative outcomes, particular post-operative complications, in comparison with those who had CPET.
Patients who have undergone pancreatoduodenectomy from April 2016 to March 2020 will be included. This will be a single-centre study and will be conducted at Royal Blackburn hospital.REC name
London - Brighton & Sussex Research Ethics Committee
REC reference
21/PR/0360
Date of REC Opinion
23 Mar 2021
REC opinion
Favourable Opinion