Clinical Consequences of Aspergillus Disease in Cystic Fibrosis
Research type
Research Study
Full title
Clinical Consequences of Aspergillus Colonisation and Disease in Cystic Fibrosis and the Role of Environment in Acquisition and Infection
IRAS ID
232722
Contact name
Lisa Collier
Contact email
Sponsor organisation
Manchester University NHS Foundation Trust
Duration of Study in the UK
0 years, 8 months, 3 days
Research summary
Aspergillus is a common fungal pathogen found in the environment, and cystic fibrosis patient's lungs are particularly vulnerable to infection. This study aims to determine the clinical consequences of Aspergillus colonisation and disease in cystic fibrosis patients. A previous study (REC reference number 07/Q1403/70) suggested 4 classifications of Aspergillus disease in cystic fibrosis, and those same patients will be followed up for the first time to determine clinical outcomes and clinical decline in each class of disease. The surviving patients will then be retyped with blood and sputum samples to see if they have changed their type of disease over time.
The study will also investigate the role of environmental and ventilation factors in the acquisition of Aspergillus disease, looking at current environmental data from the cystic fibrosis unit and prospectively from the patient's home environments.REC name
North West - Greater Manchester South Research Ethics Committee
REC reference
18/NW/0144
Date of REC Opinion
27 Feb 2018
REC opinion
Favourable Opinion