Clearing Haemoglobin In Superficial Siderosis (CHISS)

• Research type

  Research Study

• Full title

  A Longitudinal Case-Control Study to Collect Medical and Epidemiological Data Blood and Spinal Fluid Samples for Research into Various Neurologic Diseases - Clearing Haemoglobin In Superficial Siderosis (CHISS) substudy

• IRAS ID

  210201

• Contact name

  I Galea

• Contact email

  I.Galea@soton.ac.uk

• Sponsor organisation

  University of Southampton

• Duration of Study in the UK

  5 years, months, days

• Research summary

  Superficial siderosis is a disabling neurological condition resulting from chronic bleeding around the surface of the brain and spinal cord. Blood breaks down to haemoglobin which is thought to cause neurological toxicity directly and via the induction of inflammation2. The body has a number of systems designed to clear haemoglobin before it causes toxicity, including haptoglobin, cubilin, megalin and haemopexin. The overarching hypothesis is that haemoglobin clearance has an impact in superficial siderosis. Hence molecules such as haptoglobin may have prognostic and therapeutic applications in this condition. The aim of the study is to relate the activity and type of haemoglobin-clearing molecules to clinical and radiological aspects of superficial siderosis.

• REC name

  South West - Central Bristol Research Ethics Committee

• REC reference

  16/SW/0226

• Date of REC Opinion

  25 Jul 2016

• REC opinion

  Favourable Opinion