CLEAR-HD

• Research type

  Research Study

• Full title

  CLEAR-HD: Cortical Layer Examination At high Resolution in Huntington's Disease

• IRAS ID

  252676

• Contact name

  Peter McColgan

• Contact email

  p.mccolgan@ucl.ac.uk

• Sponsor organisation

  University College London

• Clinicaltrials.gov Identifier

  Z6364106/2019/03/211, UCL Data Protection

• Duration of Study in the UK

  1 years, 11 months, 31 days

• Research summary

  The purpose of this research study is to characterise which specific layers of the cerebral cortex are affected in adults who carry the mutated Huntington’s disease (HD) gene, many years before they develop symptoms of the disease.

  I will also investigate the how these anatomical differences in brain layers affect layer specific brain function. This will help guide the optimum time for therapeutic intervention in HD prior to the onset of irreversible brain changes.

  I will use 7 Tesla MRI to investigate the structure of specific layers of the brain. Magnetoencephalography (MEG), which measures electrical activity of the brain, will be used to look at the function of these brain layers.

• REC name

  London - Queen Square Research Ethics Committee

• REC reference

  19/LO/1448

• Date of REC Opinion

  10 Sep 2019

• REC opinion

  Further Information Favourable Opinion