CLD_ProspectiveStudy
Research type
Research Study
Full title
A pilot investigation of the prevalence and features of chronic lung disease in children and young adults with HIV infection in the UK.
IRAS ID
230832
Contact name
Paul Collini
Contact email
Sponsor organisation
Sheffield Teaching Hospitals NHS Foundation Trust
Duration of Study in the UK
1 years, 1 months, 1 days
Research summary
The aim of this study is to describe the burden of long-term lung problems or chronic lung disease (CLD) in children and young adults receiving treatment for HIV in the UK. We will focus on those whose acquired HIV infection from their mothers at or around birth, also referred to as perinatally-acquired HIV (Pa-HIV). We believe it is important to study this because recent research from Sub-Saharan Africa has shown that a significant proportion of children with Pa-HIV develop CLD despite receiving antiretroviral therapy (ART); as many as a third have chronic cough or breathlessness and a similar proportion have abnormal lung function tests. It is thought that these lung problems may be due to lasting damage from previous lung infections before starting ART but also secondary to inflammation and immune system over-activation that is driven by HIV despite ART. However, the extent and nature of any CLD among the 1400 children and young adults with Pa-HIV in the UK is not known. It is important to understand this so that CLD can be prevented or diagnosed early and treated before it gets worse.
This project is a pilot study which will provide the necessary data and understanding to design a larger study: we will invite patients with Pa-HIV receiving care in Sheffield Children’s Hospital NHS FT and Sheffield Teaching Hospitals NHS FT (at the Royal Hallamshire Hospital) to participate in the study along with a control group of similarly aged volunteers from schools in Sheffield. Participation will involve completing a secure online questionnaire about respiratory symptoms, previous lung problems, cigarette smoking and other factors associated with breathing problems and a single set of simple lung function measurements using spirometry (blowing tests) and a shuttle walk test called an incremental shuttle walk test (ISWT). Volunteers will then leave the study.REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
17/YH/0410
Date of REC Opinion
14 Dec 2017
REC opinion
Further Information Favourable Opinion