CLARITY
Research type
Research Study
Full title
Cardiovascular Longitudinal ALSPAC Research Investigations following hyperTensive pregnancy in Young adulthood (CLARITY)
IRAS ID
312572
Contact name
Paul Leeson
Contact email
Sponsor organisation
University of Oxford
Duration of Study in the UK
4 years, 4 months, 31 days
Research summary
Women who develop blood pressure problems during pregnancy are more likely to have high blood pressure (hypertension) in later life as well as heart attacks or strokes. The children born to the pregnancy also tend to have higher blood pressure and are often at increased risk of heart and blood vessel disease later in life. Our work has shown that children born to pregnancies where the mother has high blood pressure have changes in their blood vessels, heart and brain that can be measured long before they develop high blood pressure or other clinical symptoms. By understanding the pattern of changes across multiple parts of the body, over a lifetime, we can identify how advanced the underlying disease is for an individual and how their disease is likely to develop over the next few years.
Our aim is to understand the heart and blood vessel changes of people born to a hypertensive pregnancy once they are in their twenties and thirties. We then hope to use this information to develop new ways to prevent early onset heart and blood vessel disease in these people.
REC name
Wales REC 6
REC reference
22/WA/0227
Date of REC Opinion
19 Aug 2022
REC opinion
Favourable Opinion