Circulating biomarkers in Ewing sarcoma clinical trial samples
Research type
Research Study
Full title
Analysis of circulating tumour cells, DNA and RNA and protein levels in patients with Ewing sarcoma recruited to the EE2012 clinical trial
IRAS ID
291706
Contact name
Martin McCabe
Contact email
Sponsor organisation
University of Manchester
Duration of Study in the UK
3 years, 4 months, 30 days
Research summary
Ewing sarcoma is a bone cancer that usually affects children and young adults. All Ewing sarcomas have a characteristic mutation that can be detected in blood. This project will examine the level of the mutation and associated genes and proteins that can be measured in the blood of children and adults treated in the EE2012 clinical trial who have consented to the use of these biological samples, collected with the express purpose of studying circulating biomarkers. The aims of the study are to see if a blood test could be used in the future to diagnose Ewing sarcoma, or could be used to monitor whether treatment is working or whether the disease has returned.
REC name
East Midlands - Derby Research Ethics Committee
REC reference
25/EM/0028
Date of REC Opinion
30 Jan 2025
REC opinion
Favourable Opinion