Circadian Disruption on ICU - CADI
Research type
Research Study
Full title
Circadian Disruption on ICU - Is it relevant in pneumonia?
IRAS ID
219666
Contact name
Gareth Kitchen
Contact email
Sponsor organisation
University Hospital of South Manchester
Duration of Study in the UK
2 years, 6 months, 5 days
Research summary
Physical changes happen to people over the course of the day in a cyclical manner. e.g body temperature and wakefulness. These daily changes are called circadian rhythms and and also know to affect the ability of the body to respond to infection. We believe that the environment on intensive care many affect the circadian rhythms and change the way in which people are able to respond to infection. \n\nCircadian rhythms are known to affect inflammation in mice however it is unclear whether they affect humans. We propose to study patients in three groups:\n1) Admitted acutely unwell to intensive care\n2) Have longer than average stay on intensive care and require gradual reduction in help from a ventilator\n3) Healthy Volunteers to provide data for comparison of normal\n\nThese groups, will allow us to assess importance of disease and environment on the disruption to these daily rhythms.
REC name
North West - Greater Manchester South Research Ethics Committee
REC reference
17/NW/0030
Date of REC Opinion
2 Mar 2017
REC opinion
Further Information Favourable Opinion