CIMPRES-COPD
Research type
Research Study
Full title
Changes in Inflammatory Markers during Pulmonary Rehabilitation based on Exacerbation Status.
IRAS ID
196145
Contact name
Alex R Jenkins
Contact email
Sponsor organisation
University of Lincoln
Clinicaltrials.gov Identifier
Duration of Study in the UK
2 years, 2 months, 1 days
Research summary
Exercise is a cornerstone of pulmonary rehabilitation in the treatment of chronic obstructive pulmonary disease (COPD). Research has recently concluded that pulmonary rehabilitation is beneficial for improvements in functional capacity and quality of life. COPD is characterised by irreversible airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response. This inflammation can be amplified with flare-ups (acute exacerbations) that are commonly seen in COPD patients.
In healthy individuals, a relationship between exercise, immune function and risk of infection has been identified. Exercise has been shown to induce an anti-inflammatory response when performed regularly. In COPD, there is a lack of research examining the effects of exercise on inflammatory/immune responses. This study will be examining the inflammatory/immune response in blood and sputum throughout various time points during pulmonary rehabilitation. This study will split patients into 2 groups at a sample level based on exacerbation history. This is being done to identify whether there are differing responses to exercise between patients who exacerbate frequently compared to patients who exacerbate infrequently.
We will recruit 58 frequent exacerbators and 58 infrequent exacerbators to explore the effects of exercise as part of a pulmonary rehabilitation programme on immune function and clinical outcomes. By better understanding the mechanisms of how exercise affects inflammation in COPD, we could design better pulmonary rehabilitation programmes, providing evidence for assessing direct needs of sub-cohorts of patients.REC name
London - Bromley Research Ethics Committee
REC reference
16/LO/0865
Date of REC Opinion
28 Apr 2016
REC opinion
Favourable Opinion