Ciliary muscle morphology and lenticular decentration
Research type
Research Study
Full title
The relationship between ciliary muscle morphology and lenticular decentration
IRAS ID
160538
Contact name
Nabil Habib
Contact email
Sponsor organisation
University of Plymouth
Duration of Study in the UK
0 years, 6 months, 0 days
Research summary
During cataract surgery the natural crystalline lens is removed and an artificial intraocular lens (IOL) is inserted. In recent years there has been growing interest in the assessment of the optical quality of the eye before and after IOL implantation. The development of reliable aberrometers (which measure the optical quality of the eye) has driven the evolution of intraocular lenses designed to reduce ocular aberrations. However, aberration controling IOLs require precise centration as image quality is degraded by any lens decentration.
The methods of measuring centration are Scheimflug imaging; phacometry; optical coherence tomography (OCT); and image analysis taken from a view through a dilated pupil where the centre of the IOL optic can be seen (Wolffsohn and Buckhurst 2010). The literature suggests an average absolute decentration of around 0.3 mm and recent studies have shown a trend for the decentration to occur in a nasal direction (Buckhurst et al., 2010).
Anterior segment OCT has allowed high-resolution structural examination of the ciliary body in-vivo. Recent morphological studies have demonstrated that there is asymmetry between the nasal and temporal ciliary body with the temporal side being thicker than the nasal (Sheppard et al., 2010; Buckhurst et al., 2013b). Considering this structural asymmetry it is possible to imagine that there is a relationship between lens centration and ciliary body thickness. The proposed study intends to determine whether this temporal/nasal asymmetry leads to a nasal lens decentration in the eye post cataract surgery. If a link between these factors can be established then it is possible that the post-operative position of an IOL could be predicted.
Wolffsohn, J. et al., (2010). Objective analysis of toric intraocular lens rotation and centration. JCRS. 36, 778-782
Buckhurst, P.J. et al., (2010). Rotational and Centration Stability of the Aspheric Akreos AO Intraocular Lens. JCRS. 36,1523-1528.
Buckhurst, P.J. et al., (2013) Assessment of ciliary muscle morphology using a new Fourier domain swept source anterior chamber optical coherence tomographer. IOVS E-abstract3035.
Sheppard, A. et al., (2010). In vivo analysis of ciliary muscle morphological changes with accommodation and axial ametropia. IOVS 51, 6882-6889.REC name
South East Scotland REC 01
REC reference
15/SS/0141
Date of REC Opinion
7 Aug 2015
REC opinion
Favourable Opinion