CHIPS Dataset
Research type
Research Database
IRAS ID
360911
Contact name
Gabriela Toledo
Contact email
Research summary
Collaborative HIV Paediatric Study (CHIPS) Dataset
REC name
West of Scotland REC 4
REC reference
26/WS/0001
Date of REC Opinion
15 Jan 2026
REC opinion
Favourable Opinion
Data collection arrangements
The CHIPS dataset includes 2,212 children diagnosed with HIV and age under 16 years at first presentation to paediatric HIV care in the UK and Ireland up to the end of March 2021. Data were collected from 2000 to 2021 and include personal identifiers such as date of birth, hospital ID number, partial postcode (excluding the final letter), sex, country of birth, and date of death. Longitudinal clinical data collected from patient records include clinical markers (CDC B/C events, hospitalisations, height, weight, CD4 counts, viral loads, co-infections, lipodystrophy, lipids), reproductive and sexual health (onset of menarche, pregnancy), treatment history (antiretroviral regimen changes, start/stop dates, reasons), HIV testing, current follow-up status, and details of deaths. Additional data are collected on clinical and laboratory adverse events.
Research programme
CHIPS was both a national surveillance and research study launched in 2000 to monitor the health and care of children living with HIV in the UK and Ireland. It closed in 2021, when reporting transferred to the Children’s HIV and AIDS Reporting System. The historic CHIPS dataset continues to support ongoing research. The primary focus of ongoing research is as follows: • Clinical research on the health status of people with childhood acquired HIV, including retention in care, treatment changes, immunological and virological status, morbidity and mortality • Antiretroviral drug safety studies, often in collaboration with the Epidemiology of Pregnancy and Paediatric Infections International Cohort Collaboration (EPPICC) The CHIPS team applied to CAG to establish the legal basis for processing personal identifiers collected without patient consent in the CHIPS dataset. Findings from ongoing CHIPS analyses will contribute to international and national paediatric HIV clinical guidelines and help improve care of children and young people living with HIV acquired in childhood.
Research database title
Collaborative HIV Paediatric Study (CHIPS) Dataset
Establishment organisation
Medical Research Council Clinical Trials Unit at UCL
Establishment organisation address
90 High Holborn
London
WC1V 6LJ