Children & young people with Long Covid (CLoCk) study [COVID-19] [UPH]

  • Research type

    Research Study

  • Full title

    Children & young people with Long Covid (CLoCk) study



  • Contact name

    Roz Shafran

  • Contact email

  • Sponsor organisation

    UCL Great Ormond Street Institute of Child Health

  • ISRCTN Number


  • Duration of Study in the UK

    2 years, 11 months, 28 days

  • Research summary

    BACKGROUND: Little is known about long COVID even in adults. Risk factors for worse COVID at all ages include obesity, pre-existing comorbidities, learning and neurological disabilities, mental health problems and ethnic minority status. In addition, the children and young people (CYP) likely to be most at risk of long COVID are teenagers – who have always had more risk of persistent fatigue and mental health problems after viral infections.

    AIMS: It seems likely that some people remain ill for a long time after infection with the COVID virus. They are said to have ‘long COVID’. We have seen something similar before in CYP, for example, following a common childhood infection called glandular fever. Doctors do not know how to diagnose long COVID in CYP, how common it is or how long it goes on for. There is no simple test for long COVID. We need to know a lot more about it if we want to work out how to treat it.

    WHO, WHERE AND HOW: We will ask 30,000 CYP (aged 11-17), half of whom we know had COVID, whether they still have physical and mental health problems at 3, 6, 12 and 24 months afterwards using several online questionnaires. We can compare responders who had a positive COVID test with responders who did not test positive. We can then agree on a medical diagnosis of what long COVID is and how we might treat it.

  • REC name

    Yorkshire & The Humber - South Yorkshire Research Ethics Committee

  • REC reference


  • Date of REC Opinion

    16 Mar 2021

  • REC opinion

    Further Information Favourable Opinion