Chest ultrasonography to assess fluid status in children on dialysis
Research type
Research Study
Full title
Systematic application of chest ultrasonography to assess fluid status in paediatric dialysis patients
IRAS ID
181922
Contact name
Wesley Hayes
Contact email
Duration of Study in the UK
0 years, 8 months, 0 days
Research summary
Determining the appropriate target weight for children receiving dialysis is a significant challenge given the lack of reliable objective assessment techniques for total body fluid status.
We hypothesise that that chest ultrasound examination can be used to assess fluid status in children requiring dialysis, and guide the assessment of their target weight.
The objectives of this single centre study are:
1. To compare lung ultrasound measurements with currently available measures of patient fluid status including patient weight, blood pressure, clinical assessment, bioimpedance measurements and echocardiogram findings.
2. To develop a lung ultrasound B-lines score to quantify to quantify fluid overload in children receiving dialysis.
3. To determine if lung ultrasound findings correlate with symptoms of fluid overload or depletion such as breathlessness, headache and abnormal blood pressure.Methods:
Children aged 0 – 18 years receiving haemodialysis or peritoneal dialysis will be eligible for the study.
Brief chest ultrasound examinations will be performed before and after dialysis with a sonosite S-ICU ultrasound 2-5MHz curved probe on the skin. The number of "B lines" in the midaxillary, anterior axillary, midclavicular and parasternal spaces will be measured.
B-line numbers will be compared to clinical parameters of fluid status including patient weight, blood pressure, clinical assessment, bioimpedance measurements and echocardiogram findings. If significant correlation of B-line numbers with clinical parameters is found, a B-line score will be proposed.REC name
Wales REC 7
REC reference
15/WA/0184
Date of REC Opinion
13 May 2015
REC opinion
Favourable Opinion