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Characterizing Clot Microstructure in Atrial Fibrillation and Stroke

  • Research type

    Research Study

  • Full title

    Characterisation of clotting characteristics in atrial fibrillation patients presenting with stroke and their response to anticoagulant treatment



  • Contact name

    Phillip Adrian Evans

  • Contact email

  • Sponsor organisation

    Swansea University

  • Duration of Study in the UK

    1 years, 11 months, 31 days

  • Research summary

    Stroke and Atrial fibrillation especially in South Wales are major diseases resulting in a significant social and economic burden. It has long been argued that AF and stroke unfavourably alter how the blood clots, however, there is no available test that can provide a numerical description of blood clotting quality in a clinical setting. The main goal of this observational study is to validate a novel test of clot quality, fractal dimension (df) in atrial fibrillation patients with and without stroke. This study aims to determine whether these patients are more likely to produce substantially modified clots that results in poorer clot quality and how these patients respond to anti coagulation (blood thinning) therapy. To do this a baseline blood sample will be taken for 2 different groups: atrial fibrillation patients suffering a stroke and atrial fibrillation patients without stroke. These patients will then receive oral anticoagulant therapy, following which a second sample will be taken to determine whether they improve clotting quality. The results of the second blood test will be compared to the results of their matched baseline for each participant to ascertain what effect oral anticoagulation has on clotting quality.

  • REC name

    Wales REC 5

  • REC reference


  • Date of REC Opinion

    9 Aug 2017

  • REC opinion

    Further Information Favourable Opinion