Characterising the immune response in COVID-19 [COVID-19]
Research type
Research Study
Full title
Characterising the immune response in COVID-19
IRAS ID
283234
Contact name
Keir Lewis
Contact email
Sponsor organisation
Hywel Dda University Health Board
ISRCTN Number
ISRCTN12345678
Clinicaltrials.gov Identifier
Duration of Study in the UK
0 years, 7 months, 21 days
Research summary
Some people with COVID-19 are entirely unaffected and some people become extremely ill. There is evidence to suggest that those who become severely ill have what is often referred to as a “cytokine storm“. This means their own immune system has gone into overdrive and is causing the harm. \n\nThis research will look at the immune system response in a range of hospitalised COVID-19 patients and in biobanked samples using very advanced blood analysis not normally available in hospital settings. We hope to identify patterns of immune response in people with COVID-19 at different stages / severity of illness.\n\nWe could then compare the immune response seen in patients at different stages of the disease and in patients with different severity of disease. This may form the basis for the development of prognostic tests to identify those at risk and tailor monitoring. In the future this information may be of use to guide treatment with steroids and other drugs that act on specific parts of the immune system. \n
REC name
Yorkshire & The Humber - Leeds East Research Ethics Committee
REC reference
20/YH/0161
Date of REC Opinion
7 May 2020
REC opinion
Further Information Favourable Opinion