Characterising electrophysiological patterns in neuromuscular disease
Research type
Research Study
Full title
Characterising electrophysiological patterns in neuromuscular disease over time using serial neurophysiology studies
IRAS ID
193889
Contact name
Stephanie Blacklock
Contact email
Sponsor organisation
The Newcastle Upon Tyne Hospitals NHS Foundation Trust
Duration of Study in the UK
1 years, 5 months, 31 days
Research summary
Many patients with rare neuromuscular diseases have a failure of neurotransmission, or the ability of nerves to conduct impulses to muscles. Little is known about how this failure of neurotransmission changes over disease course, or how it is affected by current available treatments. In this study we will perform serial neurophysiological studies in volunteers with neuromuscular disorders, in order to assess how neurotransmission changes during disease course and with treatment. Research participants will have neurophysiology studies carried out after their assessment at the specialist neuromuscular clinic in Newcastle on 3 occasions 6 months apart. To support the information from the neurophysiology tests, researchers will also record the clinical information recorded at the participants clinic attendance (information on symptoms and muscle strength). The combined results from these patients will be used to provide new information on the mode of action of the standard treatments currently given to these patients, and this information will contribute towards the development of new more targeted therapies. In addition, the research will provide important information relating to disease course which can be used in providing end-points for future clinical trials.
REC name
North East - Newcastle & North Tyneside 1 Research Ethics Committee
REC reference
16/NE/0161
Date of REC Opinion
4 Aug 2016
REC opinion
Further Information Favourable Opinion