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Characterisation of thoracic malignancies using archival human tissue

  • Research type

    Research Study

  • Full title

    Histopathological and molecular and characterisation of thoracic malignancies using archival diagnostic human tissue samples

  • IRAS ID

    157104

  • Contact name

    John Le Quesne

  • Contact email

    jlq2@le.ac.uk

  • Sponsor organisation

    University of Leicester

  • Research summary

    Thoracic malignancies including lung cancer and mesothelioma together account for around 35,000 cancer related deaths in the UK and most cases are associated with a poor prognosis. This project aims to use surplus diagnostic material and anonymised patient data from a large diagnostic archive to improve our understanding of these tumours and as a result develop clinically useful prognostic and predictive biomarkers. Spare archival tissues will be incorporated into a 'tissue microarray' with an accompanying database. The project will involve studying the histopathological characteristics of these tumours as well as changes that occur within their DNA, RNA and protein.

  • REC name

    East Midlands - Leicester South Research Ethics Committee

  • REC reference

    14/EM/1159

  • Date of REC Opinion

    22 Sep 2014

  • REC opinion

    Favourable Opinion