Characterisation of thoracic malignancies using archival human tissue
Histopathological and molecular and characterisation of thoracic malignancies using archival diagnostic human tissue samples
John Le Quesne
University of Leicester
Thoracic malignancies including lung cancer and mesothelioma together account for around 35,000 cancer related deaths in the UK and most cases are associated with a poor prognosis. This project aims to use surplus diagnostic material and anonymised patient data from a large diagnostic archive to improve our understanding of these tumours and as a result develop clinically useful prognostic and predictive biomarkers. Spare archival tissues will be incorporated into a 'tissue microarray' with an accompanying database. The project will involve studying the histopathological characteristics of these tumours as well as changes that occur within their DNA, RNA and protein.
East Midlands - Leicester South Research Ethics Committee
Date of REC Opinion
22 Sep 2014