Characterisation of the mineral content of bone in hypophosphatasia V1

• Research type

  Research Study

• Full title

  Characterisation of the mineral content of bone in hypophosphatasia

• IRAS ID

  304767

• Contact name

  KES Poole

• Contact email

  kenneth.poole@nhs.net

• Sponsor organisation

  Cambridge University Hospitals NHS FT and University of Cambridge

• Duration of Study in the UK

  2 years, 11 months, 28 days

• Research summary

  Hypophosphatasia is a genetic disease which causes defects in bone mineralisation. In this study we aim to use various techniques (including scanning and transmission electron microscopy and nuclear magnetic resonance spectroscopy)to investigate the nature of the bone mineral present in a bone biopsy from a patient with hypophosphatasia and to compare it with bone from patients without the disease.

• REC name

  London - Surrey Research Ethics Committee

• REC reference

  22/HRA/0246

• Date of REC Opinion

  18 May 2022

• REC opinion

  Favourable Opinion