Characterisation of subretinal hyper-reflective material in nAMD

• Research type

  Research Study

• Full title

  The characterisation of subretinal hyperreflective material using Heidelberg Optical Coherence Tomography and Heidelberg Multicolour imaging in neovascular age-related macular degeneration.

• IRAS ID

  230688

• Contact name

  Salwa Abugreen

• Contact email

  salwa.abugreen@elht.nhs.uk

• Sponsor organisation

  East Lancashire Hospitals NHS trust

• Duration of Study in the UK

  0 years, 9 months, 2 days

• Research summary

  Age-related macular degeneration (AMD) is an increasing cause of visual impairment in the elderly populations of the developed world. There are two types of AMD; atrophic and neovascular AMD. Neovascular AMD is currently the only treatable type. Within neovascular AMD, a process of leaky blood vessels can cause the accumulation of fluid and materials (exudation). This is commonly identified as subretinal hyper-reflective material, the presence of which is associated with treatment-resistance and poor vision as compared to patients without subretinal hyper-reflective material. We aim to study the observed differences in subretinal hyper-reflective material across two imaging modalities; optical coherence tomography and multicolour imaging and assess how these change over time. We also aim to see if these features change over time and if they are associated with changes in vision.

• REC name

  North West - Haydock Research Ethics Committee

• REC reference

  17/NW/0703

• Date of REC Opinion

  15 Jan 2018

• REC opinion

  Further Information Favourable Opinion