Characterisation of HIV-1 infection of immune cells
Research type
Research Study
Full title
Characterisation of HIV-1 infection of immune cells
IRAS ID
229855
Contact name
Q Sattentau
Contact email
Sponsor organisation
University of Oxford
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
2 years, 1 months, 28 days
Research summary
The aims of this project are two-fold. Firstly, to investigate the signals involved in uptake of HIV-1-infected T cells by macrophages. Secondly, to study the effects of HIV-1 infection on monocyte/macrophage activation and trafficking. The results of the study will help to shed light on the mechanism of establishment of the macrophage reservoir and HIV-1 dissemination in vivo and provide potential targets for anti-inflammatory therapies adjunctive to antiretroviral therapy.
To achieve this blood will be taken from healthy volunteers recruited from the University of Oxford by department-wide email lists by a trained member of staff following acquisition of informed consent. In addition blood will also be obtained from the NHSBT, which already has informed consent for use of these samples in research. Once acquired, the blood will be anonymised and processed to obtain the peripheral blood mononuclear cells (PBMCs). These cells will then be cultured and infected and analysed to address the questions described above.
This work has been reviewed and funded by the Wellcome Trust Infection, Immunity and Translational Medicine PhD program and the Edward P Abraham Trust PhD program.REC name
West Midlands - Coventry & Warwickshire Research Ethics Committee
REC reference
17/WM/0333
Date of REC Opinion
22 Aug 2017
REC opinion
Favourable Opinion