Characterisation of grafts for HCT

• Research type

  Research Study

• Full title

  Characterisation and manipulation of donor grafts to improve the outcomes of allogeneic haematopoietic cell transplantation (HCT).

• IRAS ID

  253742

• Contact name

  Diana Hernandez

• Contact email

  Diana.Hernandez@anthonynolan.org

• Sponsor organisation

  Anthony Nolan

• Duration of Study in the UK

  5 years, 0 months, 0 days

• Research summary

  Bone marrow transplants (BMT) are a curative therapy for many serious blood disorders, including blood cancers. Unfortunately, only around 50% patients receiving a BMT are cured and survive long term. For the remainder, major complications include serious infections, relapse (their primary blood disorder comes back), or graft-versus-host disease (GvHD); a serious complication where the donated cells harm the recipient. In this project, we want to understand how the number, type and functional characteristics of the cells in the donated graft influence patient survival, and, if and how the graft may be manipulated to improve outcomes and treat the complications associated with transplants.

• REC name

  London - London Bridge Research Ethics Committee

• REC reference

  19/LO/1411

• Date of REC Opinion

  2 Sep 2019

• REC opinion

  Favourable Opinion