Characterisation of Cardiac Function in ICU Survivors of Sepsis
Research type
Research Study
Full title
Characterisation of Cardiac Function in ICU Survivors of Sepsis: A Pilot Study
IRAS ID
309553
Contact name
Tara Quasim
Contact email
Sponsor organisation
NHS Greater Glasgow and Clyde
Duration of Study in the UK
1 years, 11 months, 28 days
Research summary
Sepsis is a condition in which the body mounts an overwhelming inflammatory response to infection and is one of the leading causes of death worldwide. More than half of all survivors of severe sepsis will develop cognitive, psychological, or physical impairment following their illness. The impact of these symptoms, often termed post-intensive care syndrome (PICS) can have a huge impact on quality of life. For example, half of ICU survivors have not yet returned to employment one year following ICU discharge. There has been much work describing PICS, however its’ underlying mechanisms are unclear. Some symptoms associated with PICS are also common in those with damage to their heart and blood vessels from other conditions. Sepsis can put huge strain on the heart during critical illness and lead to long-term problems with the cardiovascular system. Sepsis can also cause chronic pain. It is unclear if systemic inflammation or damage to the heart that occurs during sepsis is still present after discharge home and whether it contributes to PICS.\n\nWe intend to perform Cardiovascular Magnetic Resonance (CMR) imaging in ICU survivors of sepsis. We will assess whether there is evidence of inflammation in the heart following ICU in comparison to normal subjects. We will also study blood tests called biomarkers, to assess whether there is any ongoing inflammation, damage to the heart or evidence that it is not functioning normally in comparison to healthy populations. This will help us determine if there is ongoing inflammation or heart and blood vessel injury following ICU discharge. We will explore why our findings have occurred and if injury to the heart is associated with symptoms of PICS. Understanding the underpinning processes that cause PICS will allow us to identify potential new targets for the prevention and treatment of PICS.
REC name
South West - Central Bristol Research Ethics Committee
REC reference
22/SW/0082
Date of REC Opinion
7 Jul 2022
REC opinion
Further Information Favourable Opinion