Characterisation of Bronchiectasis patients
Research type
Research Study
Full title
A study to investigate the characteristics, anthropometry and dietary intakes of a group of patients with bronchiectasis. The results of this will allow stratification of the group to inform further research including effects of a tailored amino acid supplemented intervention on clinical outcomes and functionality
IRAS ID
216351
Contact name
Linsey King
Contact email
Sponsor organisation
University of Leeds
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
A cross sectional study to establish characteristics of a Bronchiectasis patient group to assess nutritional status and disease associated outcomes.To collect routine data e.g. aetiology, sputum volumes,lung function. In addition to assess nutritional intake and anthropometrics (measures of body mass) to report on findings comparing nutritional status with lung function, recurrent infection, exercise tolerance and functionality and their interplay. In addition to determine and establish stratified sub populations for future research.
There is a dearth of evidence on the relationship between nutritional status and clinical outcomes in this patient group.Investigation into the role of nutrition with further functional and clinical outcomes is lacking. Research has outlined that 1/3rd of these patients have significant fat free mass depletion.Patients with Bronchiectasis with lower BMI’s are prone to developing more acute exacerbations and poorer pulmonary function. More specifically there is growing interest in the role of vitamin D specifically in the protection against inflammation and recurrent infections. Routine data as part of the patient care pathway will be collected using standard operating procedures where appropriate. Additional data outside of the standard patient care pathway (24 recall,hand grip dynamometry and tricep skinfold) will be collected by the researcher who is trained in collection of such data, but this will be collected within the clinic setting. Each recruited participant will receive 2 further follow up phone calls at agreed time points to gather further 24 hr recalls in order to establish averages. Standard operating procedures will also be used where applicable. Patients will be recruited by research nurses who will offer information and collect consent for the researcher to follow up in the clinic appointment.REC name
South Central - Hampshire B Research Ethics Committee
REC reference
17/SC/0131
Date of REC Opinion
19 Apr 2017
REC opinion
Further Information Favourable Opinion