Characterisation of antibody-like proteins using human PBMCs
Research type
Research Study
Full title
Characterisation of antibody-like proteins, that specifically bind to peptides commonly found in humans, using human Peripheral Blood Mononuclear cells (PBMCs)
IRAS ID
289640
Contact name
Edward McGowan
Contact email
Sponsor organisation
Isogenica
Duration of Study in the UK
5 years, 0 months, 0 days
Research summary
The focus of this research is to discover antibody-like proteins that specifically bind to peptides commonly found in humans. These proteins need to be target-specific and innocuous if administered to humans. Ultimately the discovered antibody-like proteins will be used in the treatment of immune-related disorders such as cancer and autoimmunity. This study will allow to confirm specific binding to targets in human cells and be a first evaluation tool for functional activity and activation of immune cells (lymphocytes). PBMCs (Peripheral Blood Mononuclear Cells, commonly found in peripheral blood and mostly constituted of lymphocytes) from healthy anonymised donors, from which consent for research has been obtained, will be used to characterise the mode of action in pre-clinical models.
REC name
North West - Haydock Research Ethics Committee
REC reference
20/NW/0481
Date of REC Opinion
15 Dec 2020
REC opinion
Favourable Opinion