Characterisation and validation of liver microphysiological systems
Research type
Research Study
Full title
Development, characterisation and validation of microphysiological system models of the human liver
IRAS ID
324760
Contact name
Gareth Guenigault
Contact email
Sponsor organisation
CN Bio Innovations
Duration of Study in the UK
2 years, 11 months, 23 days
Research summary
Microphysiological systems (MPS) are used to replicate human physiology using human cells grown in 3D orientation and with the flow of media replicating blood flow. They present an opportunity to test therapeutics in a human relevant model alongside animal models to increase the chance of success in clinical trials. There is a need to develop more and better healthy models of organs as well as disease models to explore particular treatments. The liver is a particular focus due to it's role in metabolising therapeutics and potential toxic effects, as well as unmet needs in areas such as fatty liver diseases. These models need to be well characterised using clinically relevant biomarkers, and using omics analysis to explore their relevance to patient data. They will also be tested using compounds with known human responses to determine whether the effects are recapitulated
REC name
West Midlands - South Birmingham Research Ethics Committee
REC reference
23/WM/0033
Date of REC Opinion
24 Jan 2023
REC opinion
Favourable Opinion