CHAP study
Research type
Research Study
Full title
Comparing Hepatitis C infectiousness in the rectum of Hepatitis C monoinfected And HIV/Hepatitis C co-infected People (CHAP study)
IRAS ID
196603
Contact name
Julie Fox
Contact email
Sponsor organisation
Guy's & St. Thomas' NHS Foundation Trust
Duration of Study in the UK
1 years, 1 months, 0 days
Research summary
It has been suggested that people living with HIV are more susceptible to getting and passing on hepatitis C (HCV) through anal sex than people who do not have HIV. The reason for this is not known. Nor is it known whether the amount of hepatitis C virus (viral load) in the blood or rectum (lower part of the bowel before the anus) differs between people with and without HIV. New and incredibly effective hepatitis C treatments have recently become available. Instead of initiating the previously available poorly tolerated, less efficacious treatments, patients increasingly chose to wait for the new treatments to become available. This has created a window of opportunity to investigate the mechanism by which hepatitis C is transmitted by anal sex in HIV infected individuals, and how the amount of hepatitis C virus in the rectum relates to the amount of virus in blood during HCV treatment.
We would like to investigate the amount of hepatitis C virus and the amount of inflammation in the rectum of people living with both HIV and hepatitis C infections. We aim to compare this with the amount of virus and inflammation in people living with hepatitis C virus alone.REC name
London - Surrey Borders Research Ethics Committee
REC reference
16/LO/1051
Date of REC Opinion
5 Aug 2016
REC opinion
Further Information Favourable Opinion