Changes in Structure & Blood flow of GBM in response to CRT
Research type
Research Study
Full title
The relationship between blood flow and structural appearance of Glioblastoma (GBM) in response to radiotherapy.
IRAS ID
222593
Contact name
Naomi Fersht
Contact email
Sponsor organisation
University College London Hospital NHS Foundation Trust (UCLH),
ISRCTN Number
ISRCTN00000000
Clinicaltrials.gov Identifier
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
The study aim is to provide an understanding of the effect of radiotherapy on blood flow to glioblastoma multiforme tumours (GBM). The presence of increased blood flow is one of the biomarkers that can predict survival to various tumour types i.e. increased blood flow to the tumour leads to increased tumour growth, tumour growth leads to reduced survival.
To achieve this, patients that have a GBM, and that are due to undergoe radiotherapy will have a kind of scan (99mTc-MIBI SPECT/CT)that is used to assess blood flow to the heart to detect ischaemia (parts of the heart muscle that dont receive blood). They will have this scan before and after radiotherapy, so that the effect of the radiotherapy may be calculated.
All patients aged over 18, who have capacity to give informed consent with glioblastoma multiforme that are referred for radiotherapy planning at UCLH NHS foundation trust would be eliginle for the study.
REC name
London - Riverside Research Ethics Committee
REC reference
17/LO/0935
Date of REC Opinion
1 Aug 2017
REC opinion
Further Information Favourable Opinion