Changes in arteries during re-feeding AN inpatient
Research type
Research Study
Full title
Changes in arterial stiffening during re-feeding of underweight patients with Anorexia Nervosa in an inpatient setting : a pilot study
IRAS ID
259817
Contact name
Lee D Hudson
Contact email
Sponsor organisation
Great Ormond Street Hospital NHS Trust
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Anorexia Nervosa (AN) is a psychiatric condition leading to extreme levels of underweight and can affect children and young people. Previous research suggests that risk for cardiovascular disease (for example heart attacks or stroke) is greater in underweight people. Studies of underweight and catch-up in weight in young children have shown greater rates of cardiovascular disease (CVD) in their future. Pulse Wave Velocity (PWV) is a non-invasive and easily measured proxy for arterial stiffening and has been demonstrated to be a good predictor of future cardiovascular disease. A recent study of adolescents with AN versus controls reported greater PWV in patients with AN. This study will measure PWV in unwell children and young people with AN with underweight who have been admitted to a single specialist unit to treat AN during the initial period of re-feeding and weight gain. The study will examine for changes in arterial stiffening using PWV during the first 7 weeks of re-feeding. PWV has been measured on healthy children and young people so there is a normal range to compare the patients recruited to study, and to see how PWV changes compared the healthy population reference data. This is a pilot study to see if there are changes to inform a bigger study. This research is important as little is known about long-term physical risk from AN in children and young people, in particular how degree of underweight, and changes in weight may effect arterial stiffening.
Lay Summary of Results
Anorexia Nervosa (AN) causes harmful underweight and important cardiovascular acute complications however less is known about longer-term cardiovascular risk. We measured carotid femoral pulse wave velocity (PWV) which is a proxy for arterial stiffness in a group of underweight young women admitted to an eating disorder unit with AN at baseline and weekly as they were refed and gained weight. PWV decreased over time and in mathematical modelling, increasing BMI and calorific meal content decreased PWV (stiffness) suggesting potential positive cardiovascular benefits for refeeding and weight gain in AN. This supports current consensus for the importance of weight gain in underweight young women with AN.
Has the registry been updated to include summary results?: No
If yes - please enter the URL to summary results:
If no – why not?: N/A
Did you follow your dissemination plan submitted in the IRAS application form (Q A51)?: Yes
If yes, describe or provide URLs to disseminated materials: https://gbr01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fclick.pstmrk.it%2F3ts%2Fwww.nature.com%252Farticles%252Fs41371-023-00848-4%2FNBTI%2FItq2AQ%2FAQ%2Feb4946bf-e210-490c-bb98-a1abacc2bc5d%2F1%2Fpn_-O_UOjr&data=05%7C02%7Csurreyborders.rec%40hra.nhs.uk%7C8c6822c900244ab3515d08dcab2c38c2%7C8e1f0acad87d4f20939e36243d574267%7C0%7C0%7C638573453637697378%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=6oydFoltV6a1D%2BD5kmyUVg8JywYVPV0hlt0l8qhxvYI%3D&reserved=0
If pending, date when dissemination is expected:
If no, explain why you didn't follow it:
Have participants been informed of the results of the study?: Pending
If yes, describe and/or provide URLs to materials shared and how they were shared:
If pending, date when feedback is expected: 31/10/2024
If no, explain why they haven't:
Have you enabled sharing of study data with others?: No
If yes, describe or provide URLs to how it has been shared:
If no, explain why sharing hasn't been enabled: We have offered to do so in publication if contacted
Have you enabled sharing of tissue samples and associated data with others?: No
If yes, describe or provide a URL:
If no, explain why: N/A
Submitted on: 23/07/2024REC name
London - Surrey Borders Research Ethics Committee
REC reference
20/LO/0084
Date of REC Opinion
14 Feb 2020
REC opinion
Further Information Favourable Opinion