CHALLENGE-ICH
Research type
Research Study
Full title
Ischaemic lesions in acute intracerebral haemorrhage: pathophysiological investigation using novel multimodal cerebral and systemic haemodynamic assessments (CHALLENGE-ICH)
IRAS ID
336744
Contact name
Jatinder Minhas
Contact email
Sponsor organisation
University of Leicester
Duration of Study in the UK
4 years, 11 months, 31 days
Research summary
Treatment for strokes caused by burst blood-vessels involves reducing blood pressure to stop the bleeding into the brain. However, this reduction in blood pressure may affect blood flow to the whole of the brain, inadvertently causing blockages and injury. Fast breathing also affects brain blood flow.
I have shown that there is a medication (sodium bicarbonate) that might help improve blood flow; however, before we try to use it, we must confirm that blockages after bleeding are caused by reduced blood flow within the brain. The presence of blockages after bleeding is unexplained and considered a significant challenge for brain bleeding care, specifically as blockages raise the risk of further strokes.
I will use ultrasound and more detailed brain scans to check if treatments we already give, for high blood pressure for example, or even changes in our breathing, make blood-vessel blockages worse. This research will show how and why inadequate brain blood flow occurs after bleeding and inform how we test our chosen medication to treat this. I have extensive experience in assessing brain blood flow using brain ultrasound, altering brain blood flow using breathing techniques and importantly performing research studies in patients' who suffer brain bleeding.
REC name
Yorkshire & The Humber - Leeds East Research Ethics Committee
REC reference
24/YH/0021
Date of REC Opinion
18 Mar 2024
REC opinion
Further Information Favourable Opinion