CF Cross-sectional study
Research type
Research Study
Full title
Association between physical activity, sedentary behaviour and physiological outcome measures of cardiovascular and respiratory function in patients with Cystic Fibrosis
IRAS ID
219672
Contact name
James Shelley
Contact email
Sponsor organisation
Liverpool Heart and Chest Hospital NHS Foundation Trust
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Title
Association between physical activity, sedentary behaviour and physiological outcome measures of cardiovascular and respiratory function in patients with Cystic Fibrosis.Summary
A growing body of evidence supports the benefits of physical activity in Cystic Fibrosis, including a positive impact on lung function, reduction in pulmonary exacerbations and hospitalisations, improved exercise capacity and improved quality of life (Radtke et al., 2016). Despite this, adults with Cystic Fibrosis have been shown to be less active than their non-CF peers with physical activity declining further with age (Troosters et al., 2009).The aims of the research are therefore to assess physical activity and sedentary behaviour in adults with Cystic Fibrosis and to explore the relationship with cardiovascular and respiratory function, quality of life and clinical outcome measures.
Adult (≥18 years) participants will be recruited from outpatient CF clinics at Liverpool Heart and Chest NHS Foundation Trust (LHCH). Participants will be required to adhere to the study protocol and be clinically stable at the time of recruitment as determined by the consultant running the clinic.
Physical activity and sedentary behaviour will be assessed using valid and reliable wearable devices combined with a self-report questionnaire which is currently used as part of routine clinical care. Participants will be asked to wear two devices during waking hours for 7 days, which will monitor physical activity and sedentary behaviour. Vascular function will be examined using non-invasive ultrasound to determine ‘flow-mediated dilatation (FMD)’ which will be collected alongside routine clinical measures (stature, body mass, body mass index (BMI) and lung function). Exercise capacity will be assessed using a cycle ergometer to assess aerobic capacity. The Cystic Fibrosis Questionnaire - Revised (CFQ-R) will also be used to assess health related quality of life. All data will be collected during a single routine clinic appointment.REC name
North West - Greater Manchester West Research Ethics Committee
REC reference
17/NW/0360
Date of REC Opinion
15 Jun 2017
REC opinion
Further Information Favourable Opinion