CESOTUG Study v1.0
Research type
Research Study
Full title
Investigation into the Effect of Previous Cataract Surgery upon Aqueous Humour Cytokine Expression and Surgical Outcome in Trabeculectomy for Uveitic Glaucoma
IRAS ID
216727
Contact name
Hari Jayaram
Contact email
Sponsor organisation
Moorfields Eye Hospital NHS Foundation Trust
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
The surgical management of glaucoma associated with inflammation in the eye is a clinical challenge. This group of patients has a greater risk of surgery being less successful over time in comparison to patients with other types of glaucoma. In addition, patients who have undergone previous cataract surgery are at further risk of glaucoma surgery being less successful. Research to date has suggested that this additional risk may be due to inflammatory factors found within the clear fluid in the front of the eye in patients who have undergone prior cataract surgery. However to date, it is not known which precise factors are involved, and identification of these may help tailor our pre-operative treatment of patients with glaucoma related to inflammation and therefore help to improve the outcomes of surgery in this challenging patient group.
This pilot study aims to evaluate the levels of over sixty different inflammatory factors within the clear fluid at the front of the eye obtained from patients with glaucoma due to inflammation, who are due to undergo glaucoma surgery. Careful comparison of two groups of patients – one group who have undergone prior cataract surgery, and another who have not, will enable the identification of specific factors that differ between the two groups. Monitoring of the success of their glaucoma surgery over the first post-operative year will enable a comparison of the success rates between these two patient groups and help to identify factors that may serve as potential markers of less successful surgery.
The findings of this study will provide help in developing approaches aimed at improving the rates of successful glaucoma surgery in patients with glaucoma related to inflammation in the eye.
REC name
South Central - Hampshire B Research Ethics Committee
REC reference
16/SC/0673
Date of REC Opinion
30 Nov 2016
REC opinion
Favourable Opinion